Integrating Genomic Data into Public Health Surveillance for Multidrug-Resistant Organisms, Washington, USA
Abstract
Mitigating antimicrobial resistance (AMR) is a public health priority to preserve antimicrobial treatment options. The Washington State Department of Health in Washington, USA, piloted a process to leverage longitudinal genomic surveillance on the basis of whole-genome sequencing (WGS) and a genomics-first cluster definition to enhance AMR surveillance.
Fundamentals of Bacterial Genomics
In this three part short course, Steph Lunn introduces the molecular microbiology and genomics of bacterial pathogens, including:
- What encompasses a bacterial genome, and how is it organized?
- What are the important assumptions and principles of bacterial genomes when performing bioinformatic analysis and using them for genomic epidemiology?
- An introduction to the core, accessory, and pan genome.
- A discussion of horizontal gene transfer, including impacts to the genome and implications for genomic epidemiological inference.