Lessons learned from a one-year pilot of population-based genomic surveillance of Shigella for local public health response in King County, Washington

Public Health – Seattle & King County partnered with the Washington State Department of Health and the Washington State Public Health Lab to pilot population-based genomic surveillance of reported shigellosis at the county-level for one year. We found that the pilot was feasible and useful at the local level, given dedicated funding support.

At a glance:

Integrating Genomic Data into Public Health Surveillance for Multidrug-Resistant Organisms, Washington, USA

Abstract 

Mitigating antimicrobial resistance (AMR) is a public health priority to preserve antimicrobial treatment options. The Washington State Department of Health in Washington, USA, piloted a process to leverage longitudinal genomic surveillance on the basis of whole-genome sequencing (WGS) and a genomics-first cluster definition to enhance AMR surveillance.

Fundamentals of Bacterial Genomics

In this three part short course, Steph Lunn introduces the molecular microbiology and genomics of bacterial pathogens, including:

  • What encompasses a bacterial genome, and how is it organized?
  • What are the important assumptions and principles of bacterial genomes when performing bioinformatic analysis and using them for genomic epidemiology?
  • An introduction to the core, accessory, and pan genome.
  • A discussion of horizontal gene transfer, including impacts to the genome and implications for genomic epidemiological inference.
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